Neurochondrin Blocking Peptide for STJ501950 peptide (STJ504422)

SKU:
STJ504422-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Neurochondrin Blocking Peptide for STJ501950 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Ncdn
Gene ID: 89791
Uniprot ID: NCDN_RAT
Specificity: This blocking peptide is recommended for use in combination with Neurochondrin antibody, STJ501950
Immunogen: Synthetic peptide corresponding to unique amino acid sequence on rat NORBIN protein.
Tissue Specificity Expressed in brain and in peripheral nervous system (at protein level). Weakly expressed in neurites.
Post Translational Modifications Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7.
Function Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.
Peptide Name Neurochondrin
Neurite Outgrowth-Related Protein From The Rat Brain
Norbin
Cellular Localisation Cytoplasm
Cytosol
Endosome Membrane
Lipid-Anchor
Cell Projection
Dendrite
Postsynapse
Localizes To Somatic Regions Of Neurons
Localization To Endosome Membrane Requires Palmitoylation
Alternative Peptide Names Neurochondrin protein
Neurite Outgrowth-Related Protein From The Rat Brain protein
Norbin protein
Ncdn protein

Information sourced from Uniprot.org

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