MRAP2 Positive Control for STJ501797 is synthetically produced from the sequence and is suitable for use in western blot applications.
Applications
WB
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Dilution Range
WB: 1:500
Formulation
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
This is positive control is recommended for use in combination with MRAP2 antibody STJ501797.
Additional Info
Tissue Specificity
Largely restricted to fat tissues. Predominantly expressed in mouse epididymal (white adipose tissue) and interscapular (brown adipose tissue) fat pads. Expression is weak or absent in lung, spleen, intestine, kidney, heart and skeletal muscle.
Function
Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.
Cell MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum MembraneThe Formation Of Antiparallel Homo- And Heterodimers Suggest That N- And C-Terminus Can Both Localize In The Cytoplasmic And Extracellular PartsDepending On The ContextUpon Insulin StimulationIt Is Redistributed Into Spotty Structures Throughout The Cytoplasm
Alternative Peptide Names
Melanocortin-2 Receptor Accessory Protein proteinFat Cell-Specific Low Molecular Weight Protein proteinFat Tissue-Specific Low Mw Protein proteinMrap proteinFalp protein
