| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
MRAP2 Positive Control for STJ501797 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Mrap |
| Gene ID: |
77037 |
| Uniprot ID: |
MRAP_MOUSE |
| Specificity: |
This is positive control is recommended for use in combination with MRAP2 antibody STJ501797. |
| Tissue Specificity | Largely restricted to fat tissues. Predominantly expressed in mouse epididymal (white adipose tissue) and interscapular (brown adipose tissue) fat pads. Expression is weak or absent in lung, spleen, intestine, kidney, heart and skeletal muscle. |
| Function | Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. |
| Peptide Name | Melanocortin-2 Receptor Accessory ProteinFat Cell-Specific Low Molecular Weight ProteinFat Tissue-Specific Low Mw Protein |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum MembraneThe Formation Of Antiparallel Homo- And Heterodimers Suggest That N- And C-Terminus Can Both Localize In The Cytoplasmic And Extracellular PartsDepending On The ContextUpon Insulin StimulationIt Is Redistributed Into Spotty Structures Throughout The Cytoplasm |
| Alternative Peptide Names | Melanocortin-2 Receptor Accessory Protein proteinFat Cell-Specific Low Molecular Weight Protein proteinFat Tissue-Specific Low Mw Protein proteinMrap proteinFalp protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
