Mouse MMP-2 (72 Kda Type Iv Collagenase) Antibody Pair (STJAP00289)

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STJAP00289-50
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Host: Goat/Goat
Applications: ELISA
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This MMP-2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Polyclonal/Polyclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: Mmp2
Gene ID: 17390
Uniprot ID: MMP2_MOUSE
Immunogen: Capture immunogen: Recombinant Mouse MMP-2 protein.
Detection Immunogen: Recombinant Mouse MMP-2 protein.
Function Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues. PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta-3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
Protein Name 72 Kda Type Iv Collagenase
72 Kda Gelatinase
Gelatinase A
Matrix Metalloproteinase-2
Mmp-2 Cleaved Into - Pex
Database Links Reactome: R-MMU-1442490
Reactome: -MMU-1474228
Reactome: -MMU-1592389
Reactome: -MMU-3928665
Reactome: -MMU-9009391
Cellular Localisation Isoform 1: Secreted
Extracellular Space
Extracellular Matrix
Membrane
Nucleus
Colocalizes With Integrin Alphav/Beta3 At The Membrane Surface In Angiogenic Blood Vessels And Melanomas
Found In Mitochondria
Along Microfibrils
And In Nuclei Of Cardiomyocytes
Isoform 2: Cytoplasm
Mitochondrion
Alternative Antibody Pair Names 72 Kda Type Iv Collagenase antibody pair
72 Kda Gelatinase antibody pair
Gelatinase A antibody pair
Matrix Metalloproteinase-2 antibody pair
Mmp-2 Cleaved Into - Pex antibody pair
Mmp2 antibody pair

Information sourced from Uniprot.org

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