| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse Low-density lipoprotein receptor/LDLR-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Gene Symbol: |
Ldlr |
| Gene ID: |
16835 |
| Uniprot ID: |
LDLR_MOUSE |
| Immunogen: |
Recombinant Mouse Low-density lipoprotein receptor/LDLR Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala22-Arg790) of mouse LDLR/LDL Receptor (Accession #NP_034830.2) fused with a 6×His tag at |
| Function | Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. |
| Protein Name | Low-Density Lipoprotein ReceptorLdl Receptor |
| Database Links | Reactome: R-MMU-8856825Reactome: -MMU-8856828Reactome: -MMU-8964026Reactome: -MMU-8964038 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembraneClathrin-Coated PitGolgi ApparatusEarly EndosomeLate EndosomeLysosomeRapidly Endocytosed Upon Ligand Binding |
| Alternative Protein Names | Low-Density Lipoprotein Receptor proteinLdl Receptor proteinLdlr protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
