| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <1 EU/Mu g |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Mouse LDLR at 5 Mu g/mL (100 Mu L/well) can bind Mouse PCSK9 with a linear range of 4.88-271.36 ng/mL. |
| Gene Symbol: | Ldlr |
| Gene ID: | 16835 |
| Uniprot ID: | LDLR_MOUSE |
| Immunogen: | Recombinant Mouse Low-density lipoprotein receptor/LDLR Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala22-Arg790) of mouse LDLR/LDL Receptor (Accession #NP_034830.2) fused with a 6×His tag at |
| Immunogen Sequence: | AAEDSCSRNEFQCRDGKCIA SKWVCDGSPECPDGSDESPE TCMSVTCQSNQFSCGGRVSR CIPDSWRCDGQVDCENDSDE QGCPPKTCSQDDFRCQDGKC ISPQFVCDGDRDCLDGSDEA HCQATTCGPAHFRCNSSICI PSLWACDGDVDCVDGSDEWP QNCQGRDTASKGVSSPCSSL EFHCGSSECIHRSWVCDGEA DCKDKSDEEHCAVATCRPDE FQCADGSCIHGSRQCDREH |
| Function | Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization. |
| Protein Name | Low-Density Lipoprotein ReceptorLdl Receptor |
| Database Links | Reactome: R-MMU-8856825Reactome: -MMU-8856828Reactome: -MMU-8964026Reactome: -MMU-8964038 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembraneClathrin-Coated PitGolgi ApparatusEarly EndosomeLate EndosomeLysosomeRapidly Endocytosed Upon Ligand Binding |
| Alternative Protein Names | Low-Density Lipoprotein Receptor proteinLdl Receptor proteinLdlr protein |
Information sourced from Uniprot.org
