| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized mouse IL-33 at 10 Mu g/mL (100 Mu L/well) can bind mouse IL1RL1 with a linear range of 19.5-1197.7 ng/mL. |
| Gene Symbol: | Il1rl1 |
| Gene ID: | 17082 |
| Uniprot ID: | ILRL1_MOUSE |
| Immunogen Region: | Ser27-Ala332 |
| Immunogen: | Recombinant Mouse IL1RL1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ala332) of mouse IL1RL1 (Accession #NP_001020773.1) fused with and a hFc tag at the C-terminus. |
| Immunogen Sequence: | SKSSWGLENEALIVRCPQRG RSTYPVEWYYSDTNESIPTQ KRNRIFVSRDRLKFLPARVE DSGIYACVIRSPNLNKTGYL NVTIHKKPPSCNIPDYLMYS TVRGSDKNFKITCPTIDLYN WTAPVQWFKNCKALQEPRFR AHRSYLFIDNVTHDDEGDYT CQFTHAENGTNYIVTATRSF TVEEKGFSMFPVITNPPYNH TMEVEIGKPASIACSACFGK GSHFLADVLWQINKTVVGN |
| Post Translational Modifications | Phosphorylated by GSK3B at Ser-442.leading to proteasomal degradation. Ubiquitinated at Lys-326 in a FBXL19-mediated manner.leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response. |
| Function | Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Isoform B: Inhibits IL-33 signaling. |
| Protein Name | Interleukin-1 Receptor-Like 1 Interleukin-33 Receptor Alpha Chain Lymphocyte Antigen 84 Protein St2 Protein T1 |
| Database Links | Reactome: R-MMU-1257604 Reactome: -MMU-6811558 Reactome: -MMU-9014843 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Isoform B: Secreted |
| Alternative Protein Names | Interleukin-1 Receptor-Like 1 protein Interleukin-33 Receptor Alpha Chain protein Lymphocyte Antigen 84 protein Protein St2 protein Protein T1 protein Il1rl1 protein Ly84 protein St2 protein Ste2 protein |
Information sourced from Uniprot.org