Mouse IL1RL1 protein (Recombinant) (C-hFc) (STJP002875)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse IL1RL1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ala332) of mouse IL1RL1 (Accession #NP_001020773.1) fused with and a hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Mouse IL1RL1-C-hFc protein was developed in hek293 cells using the region Ser27-Ala332. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized mouse IL-33 at 10 Mu g/mL (100 Mu L/well) can bind mouse IL1RL1 with a linear range of 19.5-1197.7 ng/mL. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | Il1rl1 |
| Gene ID | 17082 |
| Uniprot ID | ILRL1_MOUSE |
| Immunogen | Recombinant Mouse IL1RL1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ala332) of mouse IL1RL1 (Accession #NP_001020773.1) fused with and a hFc tag at the C-terminus. |
| Immunogen Region | Ser27-Ala332 |
| Immunogen Sequence | SKSSWGLENEALIVRCPQRG RSTYPVEWYYSDTNESIPTQ KRNRIFVSRDRLKFLPARVE DSGIYACVIRSPNLNKTGYL NVTIHKKPPSCNIPDYLMYS TVRGSDKNFKITCPTIDLYN WTAPVQWFKNCKALQEPRFR AHRSYLFIDNVTHDDEGDYT CQFTHAENGTNYIVTATRSF TVEEKGFSMFPVITNPPYNH TMEVEIGKPASIACSACFGK GSHFLADVLWQINKTVVGN |
Additional Info
| Post Translational Modifications | Phosphorylated by GSK3B at Ser-442.leading to proteasomal degradation. Ubiquitinated at Lys-326 in a FBXL19-mediated manner.leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response. |
| Function | Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Isoform B: Inhibits IL-33 signaling. |
| Protein Name | Interleukin-1 Receptor-Like 1Interleukin-33 Receptor Alpha ChainLymphocyte Antigen 84Protein St2Protein T1 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-6811558Reactome: -MMU-9014843 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform B: Secreted |
| Alternative Protein Names | Interleukin-1 Receptor-Like 1 proteinInterleukin-33 Receptor Alpha Chain proteinLymphocyte Antigen 84 proteinProtein St2 proteinProtein T1 proteinIl1rl1 proteinLy84 proteinSt2 proteinSte2 protein |
Information sourced from Uniprot.org