| Host: |
Rabbit/Rabbit |
| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
This IL-16 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Conjugation: |
Unconjugated/Biotin |
| Formulation: |
Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Purification: |
Capture Purification: Protein A or G.Detection Purification: Protein A or G. |
| Concentration: |
0.5 mg/mL |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Determination Method: |
Colormetric |
| Gene Symbol: |
Il16 |
| Gene ID: |
16170 |
| Uniprot ID: |
IL16_MOUSE |
| Immunogen: |
Capture immunogen: Recombinant Mouse IL-16 protien.Detection Immunogen: Recombinant Mouse IL-16 protien. |
| Sample Type: |
Serum, plasma and other biological fluids |
| Post Translational Modifications | Synthesized as a chemo-attractant inactive precursor which is proteolytically cleaved by caspase-3 to yield IL-16. |
| Function | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Protein Name | Pro-Interleukin-16 Cleaved Into - Interleukin-16Il-16Lymphocyte Chemoattractant FactorLcf |
| Database Links | Reactome: R-MMU-449836 |
| Cellular Localisation | SecretedIsoform 1: CytoplasmColocalizes With Grin2c In Neuronal Cell Bodies And NeuritesIsoform 2: CytoplasmNucleus |
| Alternative Antibody Pair Names | Pro-Interleukin-16 Cleaved Into - Interleukin-16 antibody pairIl-16 antibody pairLymphocyte Chemoattractant Factor antibody pairLcf antibody pairIl16 antibody pair |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
