This mouse ANXA2 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes in serum, plasma and other biological fluids.
Applications
CLIA
Reactivity
Mouse
Sensitivity
0.19ng/mL
Detection Limit
0.31~20ng/mL
Note
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Product Properties
Storage Instruction
If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
This kit recognizes Mouse ANXA2 in samples. No significant cross-reactivity or interference between Mouse ANXA2 and analogues was observed.
Sample Type
Serum, plasma and other biological fluids
Additional Info
Post Translational Modifications
ISGylated.
Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation. Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis. (Microbial infection) Regulates the formation of the NLRC4 inflammasome triggered by Anaplasma phagocytophilum infection. (Microbial infection) Protects against Klebsiella pneumoniae infection. Attenuates bacteria-induced pulmonary inflammation and promotes intro-abdominal pathogen clearance. Promotes anti-inflammatory responses by facilitating TLR4 internalization and translocation into early endosomal membranes.this leads to activation of TRAM-dependent endosomal signaling and release of anti-inflammatory cytokines. (Microbial infection) Promotes macrophage phagocytic efficiency towards Cryptococcus neoformans and ability to control fungal infection inside the cells. (Microbial infection) Contributes to protection against Pseudomonas aeruginosa infection by regulating autophagy via the AKT1-mTOR-ULK1/2 signaling pathway and activation of Rho GTPases via FAM13A-mediated mechanism.
Protein Name
Annexin A2Annexin IiAnnexin-2Calpactin I Heavy ChainCalpactin-1 Heavy ChainChromobindin-8Lipocortin IiPlacental Anticoagulant Protein IvPap-IvProtein IP36
SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMelanosomeIn The Lamina Beneath The Plasma MembraneEarly Endosome(Microbial Infection) In Lipopolysaccharide (Lps)-Triggered MacrophagesAggregates As Clusters Along The Cytoplasmic Side Of The MembraneShows Substantially Enhanced Co-Localization With Tlr4 Signalosome Complex And Gets Recruited To Early Endosomes
Alternative CLIA Names
Annexin A2 CLIA kitAnnexin Ii CLIA kitAnnexin-2 CLIA kitCalpactin I Heavy Chain CLIA kitCalpactin-1 Heavy Chain CLIA kitChromobindin-8 CLIA kitLipocortin Ii CLIA kitPlacental Anticoagulant Protein Iv CLIA kitPap-Iv CLIA kitProtein I CLIA kitP36 CLIA kitAnxa2 CLIA kitAnx2 CLIA kitCal1h CLIA kit
Specificity
This kit recognizes Mouse ANXA2 in samples. No significant cross-reactivity or interference between Mouse ANXA2 and analogues was observed.
