| Short Description : | This Alpha-synuclein antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications: | ELISA |
| Host: | Rabbit/Rabbit |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal/Monoclonal |
| Clone ID : | R59-4X-6/R83-8F-8 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | Affinity Purified |
| Dilution Range: | Determined by end user |
| Formulation: | 0.01M PBS, pH 7.2 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | Snca |
| Gene ID: | 20617 |
| Uniprot ID: | SYUA_MOUSE |
| Immunogen: | Recombinant protein |
| Tissue Specificity | Expressed in brain (at protein level). Expressed in the striatum (at protein level). Highly expressed in presynaptic terminals in the central nervous system. |
| Post Translational Modifications | Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress. Ubiquitinated. The predominant conjugate is the diubiquitinated form. Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure. |
| Function | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity. |
| Protein Name | Alpha-SynucleinNon-A Beta Component Of Ad AmyloidNon-A4 Component Of Amyloid PrecursorNacp |
| Database Links | Reactome: R-MMU-9833482 |
| Cellular Localisation | CytoplasmMembraneNucleusSynapseSecretedCell ProjectionAxonMembrane-Bound In Dopaminergic NeuronsExpressed And Colocalized With Septin4 In Dopaminergic Axon TerminalsEspecially At The Varicosities |
| Alternative Antibody Pair Names | Alpha-Synuclein antibody pairNon-A Beta Component Of Ad Amyloid antibody pairNon-A4 Component Of Amyloid Precursor antibody pairNacp antibody pairSnca antibody pairSyn antibody pair |
Information sourced from Uniprot.org