KIRREL Blocking Peptide for STJ501885 peptide (STJ504406)

SKU:
STJ504406-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: KIRREL Blocking Peptide for STJ501885 is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Kirrel1
Gene ID: 170643
Uniprot ID: KIRR1_MOUSE
Immunogen Region: 200-250
Specificity: This blocking peptide is recommended for use in combination with KIRREL antibody, STJ501885
Immunogen: Synthetic peptide taken within amino acid region 200-250 on mouse Neph1 protein.
Tissue Specificity Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Post Translational Modifications Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding. N-glycosylated.
Function Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Peptide Name Kin Of Irre-Like Protein 1
Kin Of Irregular Chiasm-Like Protein 1
Nephrin-Like Protein 1
Database Links Reactome: R-MMU-373753
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Predominantly Located At Podocyte Slit Diaphragm
Alternative Peptide Names Kin Of Irre-Like Protein 1 protein
Kin Of Irregular Chiasm-Like Protein 1 protein
Nephrin-Like Protein 1 protein
Kirrel1 protein
Kirrel protein
Neph1 protein

Information sourced from Uniprot.org

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