| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | KIRREL Blocking Peptide for STJ501885 is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Kirrel1 |
| Gene ID: | 170643 |
| Uniprot ID: | KIRR1_MOUSE |
| Immunogen Region: | 200-250 |
| Specificity: | This blocking peptide is recommended for use in combination with KIRREL antibody, STJ501885 |
| Immunogen: | Synthetic peptide taken within amino acid region 200-250 on mouse Neph1 protein. |
| Tissue Specificity | Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. |
| Post Translational Modifications | Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding. N-glycosylated. |
| Function | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. |
| Peptide Name | Kin Of Irre-Like Protein 1 Kin Of Irregular Chiasm-Like Protein 1 Nephrin-Like Protein 1 |
| Database Links | Reactome: R-MMU-373753 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Predominantly Located At Podocyte Slit Diaphragm |
| Alternative Peptide Names | Kin Of Irre-Like Protein 1 protein Kin Of Irregular Chiasm-Like Protein 1 protein Nephrin-Like Protein 1 protein Kirrel1 protein Kirrel protein Neph1 protein |
Information sourced from Uniprot.org