Human ZMYND8 protein (Recombinant) (N-His) (STJP008025)

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STJP008025
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ZMYND8-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ZMYND8
Gene ID: 23613
Uniprot ID: ZMYD8_HUMAN
Immunogen Region: His111-Thr388
Immunogen: Homo sapiens (Human)
Function Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac. May also act as a transcriptional corepressor for KDM5C and EZH2. Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination. Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters. Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression. Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform. Suppresses breast cancer, and prostate cancer cell invasion and metastasis.
Protein Name Mynd-Type Zinc Finger-Containing Chromatin Reader Zmynd8
Cutaneous T-Cell Lymphoma-Associated Antigen Se14-3
Ctcl-Associated Antigen Se14-3
Protein Kinase C-Binding Protein 1
Rack7
Transcription Coregulator Zmynd8
Zinc Finger Mynd Domain-Containing Protein 8
Cellular Localisation Nucleus
Chromosome
Cytoplasm
Sequestered In The Cytoplasm Through The Interaction With Dbn1
Localizes To Sites Of Dna Damage In A Kat5-Dependent And Dna Poly (Adp-Ribose)-Dependent Manner
On Chromatin
Localizes To Demethylated Regions
Active Promoters
And Transcription Start Sites
Alternative Protein Names Mynd-Type Zinc Finger-Containing Chromatin Reader Zmynd8 protein
Cutaneous T-Cell Lymphoma-Associated Antigen Se14-3 protein
Ctcl-Associated Antigen Se14-3 protein
Protein Kinase C-Binding Protein 1 protein
Rack7 protein
Transcription Coregulator Zmynd8 protein
Zinc Finger Mynd Domain-Containing Protein 8 protein
ZMYND8 protein
KIAA1125 protein
PRKCBP1 protein
RACK7 protein

Information sourced from Uniprot.org

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