Human ZMYND8 protein (Recombinant) (N-His) (STJP008025)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ZMYND8-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ZMYND8 |
| Gene ID | 23613 |
| Uniprot ID | ZMYD8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | His111-Thr388 |
Additional Info
| Function | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac. May also act as a transcriptional corepressor for KDM5C and EZH2. Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination. Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters. Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression. Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform. Suppresses breast cancer, and prostate cancer cell invasion and metastasis. |
| Protein Name | Mynd-Type Zinc Finger-Containing Chromatin Reader Zmynd8Cutaneous T-Cell Lymphoma-Associated Antigen Se14-3Ctcl-Associated Antigen Se14-3Protein Kinase C-Binding Protein 1Rack7Transcription Coregulator Zmynd8Zinc Finger Mynd Domain-Containing Protein 8 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCytoplasmSequestered In The Cytoplasm Through The Interaction With Dbn1Localizes To Sites Of Dna Damage In A Kat5-Dependent And Dna Poly (Adp-Ribose)-Dependent MannerOn ChromatinLocalizes To Demethylated RegionsActive PromotersAnd Transcription Start Sites |
| Alternative Protein Names | Mynd-Type Zinc Finger-Containing Chromatin Reader Zmynd8 proteinCutaneous T-Cell Lymphoma-Associated Antigen Se14-3 proteinCtcl-Associated Antigen Se14-3 proteinProtein Kinase C-Binding Protein 1 proteinRack7 proteinTranscription Coregulator Zmynd8 proteinZinc Finger Mynd Domain-Containing Protein 8 proteinZMYND8 proteinKIAA1125 proteinPRKCBP1 proteinRACK7 protein |
Information sourced from Uniprot.org