Human uPAR/PLAUR/CD87 protein (Recombinant) (C-His) (STJP001063)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human uPAR/PLAUR/CD87 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu23-Arg303) of human uPAR (Accession #NP_002650.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human uPAR/PLAUR/CD87-C-His protein was developed in hek293 cells using the region Leu23-Arg303. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA.Immobilized Human PLAUR at 1 Mu g/mL (100 Mu L/well) can bind PLAUR Rabbit pAb with a linear range of 0.03-14.17ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | PLAUR |
| Gene ID | 5329 |
| Uniprot ID | UPAR_HUMAN |
| Immunogen | Recombinant Human uPAR/PLAUR/CD87 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu23-Arg303) of human uPAR (Accession #NP_002650.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Leu23-Arg303 |
| Immunogen Sequence | LRCMQCKTNGDCRVEECALG QDLCRTTIVRLWEEGEELEL VEKSCTHSEKTNRTLSYRTG LKITSLTEVVCGLDLCNQGN SGRAVTYSRSRYLECISCGS SDMSCERGRHQSLQCRSPEE QCLDVVTHWIQEGEEGRPKD DRHLRGCGYLPGCPGSNGFH NNDTFHFLKCCNTTKCNEGP ILELENLPQNGRQCYSCKGN STHGCSSEETFLIDCRGPMN QCLVATGTHEPKNQSYMVR |
Additional Info
| Tissue Specificity | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
| Function | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. |
| Protein Name | Urokinase Plasminogen Activator Surface ReceptorU-ParUparMonocyte Activation Antigen Mo3Cd Antigen Cd87 |
| Database Links | Reactome: R-HSA-162791Reactome: R-HSA-6798695Reactome: R-HSA-75205 |
| Cellular Localisation | Cell MembraneCell ProjectionInvadopodium MembraneColocalized With Fap (Seprase) Preferentially At The Cell Surface Of Invadopodia Membrane In A Cytoskeleton-Integrin- And Vitronectin-Dependent MannerIsoform 1: Cell MembraneLipid-AnchorGpi-AnchorIsoform 2: Secreted |
| Alternative Protein Names | Urokinase Plasminogen Activator Surface Receptor proteinU-Par proteinUpar proteinMonocyte Activation Antigen Mo3 proteinCd Antigen Cd87 proteinPLAUR proteinMO3 proteinUPAR protein |
Information sourced from Uniprot.org