• Human uPA/PLAU protein (Recombinant) (C-His) (STJP000921)
  • Human uPA/PLAU protein (Recombinant) (C-His) (STJP000921)
  • Human uPA/PLAU protein (Recombinant) (C-His) (STJP000921)
  • Human uPA/PLAU protein (Recombinant) (C-His) (STJP000921)

Human uPA/PLAU protein (Recombinant) (C-His) (STJP000921)

SKU:
STJP000921

£101.50 - £357.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human uPA/PLAU-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Supplied as a 0.22 Mu m filtered solution in 20mM HEPES, 150mM NaCl, 2mM CaCl, 10% Glycerol, pH 7.5. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human uPAR Protein at 1 Mu g/mL (100 Mu L/well) can bind PLAU with a linear range of 0.031-1.014 ng/mL.
Gene Symbol: PLAU
Gene ID: 5328
Uniprot ID: UROK_HUMAN
Immunogen: Recombinant Human uPA/PLAU Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Leu431) of human Urokinase/PLAU (Accession #NP_002649.1) fused with a 8×His tag at the C-terminus.
Tissue Specificity Expressed in the prostate gland and prostate cancers.
Post Translational Modifications Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding. Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4.
Function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Protein Name Urokinase-Type Plasminogen Activator
U-Plasminogen Activator
Upa Cleaved Into - Urokinase-Type Plasminogen Activator Long Chain A - Urokinase-Type Plasminogen Activator Short Chain A - Urokinase-Type Plasminogen Activator Chain B
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-75205
Cellular Localisation Secreted
Alternative Protein Names Urokinase-Type Plasminogen Activator protein
U-Plasminogen Activator protein
Upa Cleaved Into - Urokinase-Type Plasminogen Activator Long Chain A - Urokinase-Type Plasminogen Activator Short Chain A - Urokinase-Type Plasminogen Activator Chain B protein
PLAU protein

Information sourced from Uniprot.org

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