Human TSPAN30/CD63 (Cd63 Antigen) Antibody Pair (STJAP00470)
SPECIFICATIONS
HostRabbit/Rabbit
ConjugationUnconjugated/Biotin
ImmunogenCapture immunogen: Recombinant Human TSPAN30/CD63 protien.Detection Immunogen: Recombinant Human TSPAN30/CD63 protien.
General Information
| Short Description | This TSPAN30/CD63 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | CD63 |
| Gene ID | 967 |
| Uniprot ID | CD63_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human TSPAN30/CD63 protien.Detection Immunogen: Recombinant Human TSPAN30/CD63 protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Post Translational Modifications | Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). |
| Function | Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. |
| Protein Name | Cd63 AntigenGranulophysinLysosomal-Associated Membrane Protein 3Lamp-3Lysosome Integral Membrane Protein 1Limp1Melanoma-Associated Antigen Me491Oma81hOcular Melanoma-Associated AntigenTetraspanin-30Tspan-30Cd Antigen Cd63 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLysosome MembraneLate Endosome MembraneEndosomeMultivesicular BodyMelanosomeSecretedExtracellular ExosomeCell SurfaceAlso Found In Weibel-Palade Bodies Of Endothelial CellsLocated In Platelet Dense GranulesDetected In A Subset Of Pre-MelanosomesDetected On Intralumenal Vesicles (Ilvs) Within Multivesicular Bodies |
| Alternative Antibody Pair Names | Cd63 Antigen antibody pairGranulophysin antibody pairLysosomal-Associated Membrane Protein 3 antibody pairLamp-3 antibody pairLysosome Integral Membrane Protein 1 antibody pairLimp1 antibody pairMelanoma-Associated Antigen Me491 antibody pairOma81h antibody pairOcular Melanoma-Associated Antigen antibody pairTetraspanin-30 antibody pairTspan-30 antibody pairCd Antigen Cd63 antibody pairCD63 antibody pairMLA1 antibody pairTSPAN30 antibody pair |
Information sourced from Uniprot.org