| Function | E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Plays also a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination. Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2.leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim69Rfp-Like Domain-Containing Protein TrimlessRing Finger Protein 36Ring-Type E3 Ubiquitin Transferase Trim69Tripartite Motif-Containing Protein 69 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusNucleus SpeckleCytoskeletonMicrotubule Organizing CenterCentrosomeAdopts A Filamentous Distribution In The Cell Cytoplasm Where It Strongly Colocalizes With Stable Microtubules |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Trim69 proteinRfp-Like Domain-Containing Protein Trimless proteinRing Finger Protein 36 proteinRing-Type E3 Ubiquitin Transferase Trim69 proteinTripartite Motif-Containing Protein 69 proteinTRIM69 proteinRNF36 proteinHSD-34 proteinHSD34 protein |
Information sourced from Uniprot.org
