Human TRIM69 protein (Recombinant) (N-His) (STJP008280)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TRIM69-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TRIM69 |
| Gene ID | 140691 |
| Uniprot ID | TRI69_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr331-Gln500 |
Additional Info
| Function | E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination. Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2.leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim69Rfp-Like Domain-Containing Protein TrimlessRing Finger Protein 36Ring-Type E3 Ubiquitin Transferase Trim69Tripartite Motif-Containing Protein 69 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusNucleus SpeckleCytoskeletonMicrotubule Organizing CenterCentrosomeAdopts A Filamentous Distribution In The Cell Cytoplasm Where It Strongly Colocalizes With Stable Microtubules |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Trim69 proteinRfp-Like Domain-Containing Protein Trimless proteinRing Finger Protein 36 proteinRing-Type E3 Ubiquitin Transferase Trim69 proteinTripartite Motif-Containing Protein 69 proteinTRIM69 proteinRNF36 proteinHSD-34 proteinHSD34 protein |
Information sourced from Uniprot.org