Human TRIM13 protein (Recombinant) (N-His) (STJP010714)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TRIM13-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TRIM13 |
| Gene ID | 10206 |
| Uniprot ID | TRI13_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Arg153 |
Additional Info
| Function | Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation. Participates as well in T-cell receptor-mediated NF-kappa-B activation. In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim13B-Cell Chronic Lymphocytic Leukemia Tumor Suppressor Leu5Leukemia-Associated Protein 5Putative Tumor Suppressor Rfp2Ring Finger Protein 77Ring-Type E3 Ubiquitin Transferase Trim13Ret Finger Protein 2Tripartite Motif-Containing Protein 13 |
| Database Links | Reactome: R-HSA-901032 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinConcentrates And Colocalizes With P62/Sqstm1 And Zfyve1 At The Perinuclear Endoplasmic Reticulum |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Trim13 proteinB-Cell Chronic Lymphocytic Leukemia Tumor Suppressor Leu5 proteinLeukemia-Associated Protein 5 proteinPutative Tumor Suppressor Rfp2 proteinRing Finger Protein 77 proteinRing-Type E3 Ubiquitin Transferase Trim13 proteinRet Finger Protein 2 proteinTripartite Motif-Containing Protein 13 proteinTRIM13 proteinLEU5 proteinRFP2 proteinRNF77 protein |
Information sourced from Uniprot.org