| Function | Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation. Participates as well in T-cell receptor-mediated NF-kappa-B activation. In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim13B-Cell Chronic Lymphocytic Leukemia Tumor Suppressor Leu5Leukemia-Associated Protein 5Putative Tumor Suppressor Rfp2Ring Finger Protein 77Ring-Type E3 Ubiquitin Transferase Trim13Ret Finger Protein 2Tripartite Motif-Containing Protein 13 |
| Database Links | Reactome: R-HSA-901032 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinConcentrates And Colocalizes With P62/Sqstm1 And Zfyve1 At The Perinuclear Endoplasmic Reticulum |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Trim13 proteinB-Cell Chronic Lymphocytic Leukemia Tumor Suppressor Leu5 proteinLeukemia-Associated Protein 5 proteinPutative Tumor Suppressor Rfp2 proteinRing Finger Protein 77 proteinRing-Type E3 Ubiquitin Transferase Trim13 proteinRet Finger Protein 2 proteinTripartite Motif-Containing Protein 13 proteinTRIM13 proteinLEU5 proteinRFP2 proteinRNF77 protein |
Information sourced from Uniprot.org
