Human TRIB3 protein (Recombinant) (His-Tag) (STJP019012)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human TRIB3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIB3 |
| Gene ID | 57761 |
| Uniprot ID | TRIB3_HUMAN |
| Accession Number | NP_066981 |
| Immunogen | Human |
| Immunogen Region | 1-358aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMRATPLA APAGSLSRKK RLELDDNLDT ERPVQKRARS GPQPRLPPCL LPLSPPTAPD RATAVATASR LGPYVLLEPE EGGRAYQALH CPTGTEYTCK VYPVQEALAV LEPYARLPPH KHVARPTEVL AGTQLLYAFF TRTHGDMHSL VRSRHRIPEP EAAVLFRQMA TALAHCHQHG LVLRDLKLCR FVFADRERKK LVLENLED |
Additional Info
| Tissue Specificity | Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. |
| Function | Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity. Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. Can inhibit APOBEC3A editing of nuclear DNA. |
| Protein Name | Tribbles Homolog 3Trb-3Neuronal Cell Death-Inducible Putative KinaseSinkP65-Interacting Inhibitor Of Nf-Kappa-B |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-165158Reactome: R-HSA-1989781Reactome: R-HSA-199418Reactome: R-HSA-389357Reactome: R-HSA-5218920Reactome: R-HSA-9633012Reactome: R-HSA-9648895 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Tribbles Homolog 3 proteinTrb-3 proteinNeuronal Cell Death-Inducible Putative Kinase proteinSink proteinP65-Interacting Inhibitor Of Nf-Kappa-B proteinTRIB3 proteinC20orf97 proteinNIPK proteinSKIP3 proteinTRB3 protein |
Information sourced from Uniprot.org