Human THOC7 protein (Recombinant) (His-Tag) (STJP019033)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human THOC7-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing, 50% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | THOC7 |
| Gene ID | 80145 |
| Uniprot ID | THOC7_HUMAN |
| Accession Number | NP_079351 |
| Immunogen | Human |
| Immunogen Region | 1-204aa |
| Immunogen Sequence |
Additional Info
| Function | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. |
| Protein Name | Tho Complex Subunit 7Functional Spliceosome-Associated Protein 24Fsap24Ngg1-Interacting Factor 3-Like Protein 1-Binding Protein 1Nif3l1-Binding Protein 1Htrex30 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72187Reactome: R-HSA-73856 |
| Cellular Localisation | CytoplasmNucleusNucleus SpeckleInteraction With Thoc5 Is Required For Nuclear Localization |
| Alternative Protein Names | Tho Complex Subunit 7 proteinFunctional Spliceosome-Associated Protein 24 proteinFsap24 proteinNgg1-Interacting Factor 3-Like Protein 1-Binding Protein 1 proteinNif3l1-Binding Protein 1 proteinHtrex30 proteinTHOC7 proteinNIF3L1BP1 protein |
Information sourced from Uniprot.org