Human Syntaxin 17 protein (Recombinant) (His-Tag) (STJP018447)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Syntaxin 17-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STX17 |
| Gene ID | 55014 |
| Uniprot ID | STX17_HUMAN |
| Accession Number | NP_060389 |
| Immunogen | Human |
| Immunogen Region | 1-229aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylated at Tyr-157 probably by ABL1. Dephosphorylation by PTPN2.regulates exit from the endoplasmic reticulum. (Microbial infection) Cleaved by the L.pneumophila serine protease Lpg1137, impairing endoplasmic reticulum-mitochondria communication, leading to inhibit autophagy. |
| Function | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi. |
| Protein Name | Syntaxin-17 |
| Database Links | Reactome: R-HSA-204005 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinSmooth Endoplasmic Reticulum MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneCytoplasmic VesicleAutophagosome MembraneCopii-Coated Vesicle MembraneCytoplasmCytosolMitochondrion MembraneAutolysosome MembraneHas A Hairpin-Like Insertion Into MembranesLocalizes To The Completed Autophagosome Membrane Upon Cell StarvationColocalized With Rab39a And Rab39b In Autolysosomes In Autophagy-Induced Conditions |
| Alternative Protein Names | Syntaxin-17 proteinSTX17 protein |
Information sourced from Uniprot.org