Recombinant human Syntaxin 17 protein SDS-PAGE gel 3µg reducing conditions Coomassie blue stain

Human Syntaxin 17 protein (Recombinant) (His-Tag) (STJP018447)

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STJP018447
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Short Description :Recombinant-Human Syntaxin 17-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.25 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:STX17
Gene ID:55014
Uniprot ID:STX17_HUMAN
Accession Number:NP_060389
Immunogen:Human
Immunogen Region:1-229aa
Immunogen Sequence:MSEDEEK VKLRRLEPAI QKFIKIVIPT DLERLRKHQI NIEKYQRCRI WDKLHEEHIN AGRTVQQLRS NIREIEKLCL KVRKDDLVLL KRMIDPVKEE ASAATAEFLQ LHLESVEELK KQFNDEETLL QPPLTRSMTV GGAFHTTEAE ASSQSLTQIY ALPEIPQDQN AAESWETLEA DLIELSQLVT DFSLLVNSQQ EKIDSI
Post Translational Modifications Phosphorylated at Tyr-157 probably by ABL1. Dephosphorylation by PTPN2.regulates exit from the endoplasmic reticulum. (Microbial infection) Cleaved by the L.pneumophila serine protease Lpg1137, impairing endoplasmic reticulum-mitochondria communication, leading to inhibit autophagy.
Function SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi.
Protein Name Syntaxin-17
Database Links Reactome: R-HSA-204005
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Smooth Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Cytoplasmic Vesicle
Autophagosome Membrane
Copii-Coated Vesicle Membrane
Cytoplasm
Cytosol
Mitochondrion Membrane
Autolysosome Membrane
Has A Hairpin-Like Insertion Into Membranes
Localizes To The Completed Autophagosome Membrane Upon Cell Starvation
Colocalized With Rab39a And Rab39b In Autolysosomes In Autophagy-Induced Conditions
Alternative Protein Names Syntaxin-17 protein
STX17 protein

Information sourced from Uniprot.org

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