Human SUPV3L1 protein (Recombinant) (N-His) (STJP010967)

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STJP010967
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SUPV3L1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SUPV3L1
Gene ID: 6832
Uniprot ID: SUV3_HUMAN
Immunogen Region: Thr47-Glu722
Immunogen: Homo sapiens (Human)
Function Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria.regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
Protein Name Atp-Dependent Rna Helicase Supv3l1 - Mitochondrial
Suppressor Of Var1 3-Like Protein 1
Suv3-Like Protein 1
Database Links Reactome: R-HSA-9836573
Cellular Localisation Nucleus
Mitochondrion Matrix
Mitochondrion Nucleoid
Alternative Protein Names Atp-Dependent Rna Helicase Supv3l1 - Mitochondrial protein
Suppressor Of Var1 3-Like Protein 1 protein
Suv3-Like Protein 1 protein
SUPV3L1 protein
SUV3 protein

Information sourced from Uniprot.org

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