Human Sulfotransferase 1E1/SULT1E1 protein (Recombinant) (His-Tag) (STJP016433)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Sulfotransferase 1E1/SULT1E1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
Target Information
| Gene Symbol | SULT1E1 |
| Gene ID | 6783 |
| Uniprot ID | ST1E1_HUMAN |
| Accession Number | AAH27956.1 |
| Immunogen | Human |
| Immunogen Region | 1-294aa |
| Immunogen Sequence | MNSELDYYEK FEEVHGILMY KDFVKYWDNV EAFQARPDDL VIATYPKSGT TWVSEIVYMI YKEGDVEKCK EDVIFNRIPF LECRKENLMN GVKQLDEMNS PRIVKTHLPP ELLPASFWEK DCKIIYLCRN AKDVAVSFYY FFLMVAGHPN PGSLPEFVEK FMQGQVPYGS WYKHVKSWWE KGKSPRVLFL FYEDLKEDIR KEVIKLIHFL ERKPSEELVD RIIHHTSF |
Additional Info
| Tissue Specificity | Liver, intestine and at lower level in the kidney. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. |
| Protein Name | Sulfotransferase 1e1St1e1Est-1Estrogen SulfotransferaseSulfotransferase - Estrogen-Preferring |
| Database Links | Reactome: R-HSA-156584Reactome: R-HSA-9753281 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Protein Names | Sulfotransferase 1e1 proteinSt1e1 proteinEst-1 proteinEstrogen Sulfotransferase proteinSulfotransferase - Estrogen-Preferring proteinSULT1E1 proteinSTE protein |
Information sourced from Uniprot.org