| Function | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate. Can also reduce Cu(2+) to Cu(1+). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation. |
| Protein Name | Metalloreductase Steap4Six-Transmembrane Epithelial Antigen Of Prostate 4Sixtransmembrane Protein Of Prostate 2Tumor Necrosis Factor - Alpha-Induced Protein 9 |
| Database Links | Reactome: R-HSA-917977 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneEarly Endosome Membrane |
| Alternative Protein Names | Metalloreductase Steap4 proteinSix-Transmembrane Epithelial Antigen Of Prostate 4 proteinSixtransmembrane Protein Of Prostate 2 proteinTumor Necrosis Factor - Alpha-Induced Protein 9 proteinSTEAP4 proteinSTAMP2 proteinTNFAIP9 protein |
Information sourced from Uniprot.org
