Human SSBP1 protein (Recombinant) (N-His) (STJP007453)

Name: Human SSBP1 protein (Recombinant) (N-His) (STJP007453)
SKU: STJP007453
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHomo sapiens (Human)

STJP007453

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Short Description	Recombinant-Human SSBP1-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications	ELISA/Immunogen/SDS-PAGE/WB
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Function	Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair.
Protein Name	Single-Stranded Dna-Binding Protein - Mitochondrial Mt-Ssb Mtssb Pwp1-Interacting Protein 17
Database Links	Reactome: R-HSA-2151201 Reactome: R-HSA-9837999 Reactome: R-HSA-9913635
Cellular Localisation	Mitochondrion Mitochondrion Matrix Mitochondrion Nucleoid
Alternative Protein Names	Single-Stranded Dna-Binding Protein - Mitochondrial protein Mt-Ssb protein Mtssb protein Pwp1-Interacting Protein 17 protein SSBP1 protein SSBP protein

Information sourced from Uniprot.org