Human SSBP1 protein (Recombinant) (N-His) (STJP007453)

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STJP007453
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SSBP1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SSBP1
Gene ID: 6742
Uniprot ID: SSBP_HUMAN
Immunogen Region: His16-Glu148
Immunogen: Homo sapiens (Human)
Function Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair.
Protein Name Single-Stranded Dna-Binding Protein - Mitochondrial
Mt-Ssb
Mtssb
Pwp1-Interacting Protein 17
Database Links Reactome: R-HSA-2151201
Reactome: R-HSA-9837999
Cellular Localisation Mitochondrion
Mitochondrion Matrix
Mitochondrion Nucleoid
Alternative Protein Names Single-Stranded Dna-Binding Protein - Mitochondrial protein
Mt-Ssb protein
Mtssb protein
Pwp1-Interacting Protein 17 protein
SSBP1 protein
SSBP protein

Information sourced from Uniprot.org

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