Human SLC22A12 protein (Recombinant) (N-GST) (STJP006410)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC22A12-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SLC22A12 |
| Gene ID | 116085 |
| Uniprot ID | S22AC_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu281-Thr350 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent. |
| Protein Name | Solute Carrier Family 22 Member 12Organic Anion Transporter 4-Like ProteinRenal-Specific TransporterRstUrate Anion Exchanger 1Urat1Urate -Anion Antiporter Slc22a12 |
| Database Links | Reactome: R-HSA-561048Reactome: R-HSA-5619071 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Solute Carrier Family 22 Member 12 proteinOrganic Anion Transporter 4-Like Protein proteinRenal-Specific Transporter proteinRst proteinUrate Anion Exchanger 1 proteinUrat1 proteinUrate -Anion Antiporter Slc22a12 proteinSLC22A12 proteinOATL4 proteinURAT1 proteinUNQ6453 proteinPRO34004 protein |
Information sourced from Uniprot.org