| Post Translational Modifications | N-glycosylated. |
| Function | Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent. |
| Protein Name | Solute Carrier Family 22 Member 12Organic Anion Transporter 4-Like ProteinRenal-Specific TransporterRstUrate Anion Exchanger 1Urat1Urate -Anion Antiporter Slc22a12 |
| Database Links | Reactome: R-HSA-561048Reactome: R-HSA-5619071 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Solute Carrier Family 22 Member 12 proteinOrganic Anion Transporter 4-Like Protein proteinRenal-Specific Transporter proteinRst proteinUrate Anion Exchanger 1 proteinUrat1 proteinUrate -Anion Antiporter Slc22a12 proteinSLC22A12 proteinOATL4 proteinURAT1 proteinUNQ6453 proteinPRO34004 protein |
Information sourced from Uniprot.org
