Human SLC13A3 protein (Recombinant) (N-His-KSI) (STJP016139)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC13A3-N-His-KSI protein was developed from e.coli for the region N-His-KSI. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | SLC13A3 |
| Gene ID | 64849 |
| Uniprot ID | S13A3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ile158-Ile230 |
Additional Info
| Function | High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood. Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response. |
| Protein Name | Na(+/Dicarboxylate Cotransporter 3Nadc-3Hnadc3Na(+-Coupled Carboxylate Transporter 3Nac3Sodium-Dependent High-Affinity Dicarboxylate Transporter 2Solute Carrier Family 13 Member 3Slc13a3 |
| Database Links | Reactome: R-HSA-433137 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Na(+/Dicarboxylate Cotransporter 3 proteinNadc-3 proteinHnadc3 proteinNa(+-Coupled Carboxylate Transporter 3 proteinNac3 proteinSodium-Dependent High-Affinity Dicarboxylate Transporter 2 proteinSolute Carrier Family 13 Member 3 proteinSlc13a3 proteinSLC13A3 proteinNADC3 proteinSDCT2 protein |
Information sourced from Uniprot.org