Human S100A1 (S100A1) Antibody Pair (STJAP00817)
SPECIFICATIONS
ClonalityMonoclonal/Monoclonal
HostRabbit/Rabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein
General Information
| Short Description | This S100A1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R39-3P-7/R68-6V-1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | S100A1 |
| Gene ID | 6271 |
| Uniprot ID | S10A1_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain. |
| Post Translational Modifications | Glutathionylated.glutathionylation increases affinity to calcium about 10-fold. |
| Function | Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole. |
| Protein Name | Protein S100-A1S-100 Protein Alpha ChainS-100 Protein Subunit AlphaS100 Calcium-Binding Protein A1 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-166058Reactome: R-HSA-5602498Reactome: R-HSA-5603041Reactome: R-HSA-5686938 |
| Cellular Localisation | CytoplasmSarcoplasmic ReticulumMitochondrion |
| Alternative Antibody Pair Names | Protein S100-A1 antibody pairS-100 Protein Alpha Chain antibody pairS-100 Protein Subunit Alpha antibody pairS100 Calcium-Binding Protein A1 antibody pairS100A1 antibody pairS100A antibody pair |
Information sourced from Uniprot.org