Name: Human RAB4A protein (Recombinant) (His-Tag) (STJP017239)
SKU: STJP017239
Availability: InStock

Human RAB4A protein (Recombinant) (His-Tag) (STJP017239)

SKU:

STJP017239

£134.50 - £738.50

Short Description :	Recombinant-Human RAB4A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:	SDS-PAGE
Host:	E.coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration:	1 mg/mL
Formulation:	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol 0.1M NaCl, 1mM DTT
Storage Instruction:	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol:	RAB4A
Gene ID:	5867
Uniprot ID:	RAB4A_HUMAN
Accession Number:	NP_004569
Immunogen:	Human
Immunogen Region:	1-218aa
Immunogen Sequence:	MSQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF GSKIINVGGK YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET YNALTNWLTD ARMLASQNIV IILCGNKKDL DADREVTFLE ASRFAQENEL MFLETSALTG ENVEEAFVQC ARKILNKIES GELDPERMGS GIQYGDAALR QLRSPR

Post Translational Modifications	Phosphorylated by CDK1 kinase during mitosis. Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB4A is involved in protein transport. Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets.
Protein Name	Ras-Related Protein Rab-4a
Database Links	Reactome: R-HSA-1445148 Reactome: R-HSA-1660499 Reactome: R-HSA-8854214 Reactome: R-HSA-8873719 Reactome: R-HSA-8875656
Cellular Localisation	Membrane Peripheral Membrane Protein Cytoplasm Early Endosome Membrane Recycling Endosome Membrane Generally Associated With Membranes Cytoplasmic When Phosphorylated By Cdk1
Alternative Protein Names	Ras-Related Protein Rab-4a protein RAB4A protein RAB4 protein

Information sourced from Uniprot.org

Model	Name	Host	Application
STJP008366	Human RAB4A protein (Recombinant) (N-His) (STJP008366)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP019170	Human FGB protein (Recombinant) (His-Tag) (STJP019170)	E.coli	SDS-PAGE
STJP019149	Human PYCR2 protein (Recombinant) (His-Tag) (STJP019149)	E.coli	SDS-PAGE
STJP019163	Human ALDH6A1 protein (Recombinant) (His-Tag) (STJP019163)	E.coli	SDS-PAGE
STJP019189	Human UBE2Q2 protein (Recombinant) (His-Tag) (STJP019189)	E.coli	SDS-PAGE

Human RAB4A protein (Recombinant) (His-Tag) (STJP017239)

General Information