Human RAB4A protein (Recombinant) (His-Tag) (STJP017239)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RAB4A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol 0.1M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB4A |
| Gene ID | 5867 |
| Uniprot ID | RAB4A_HUMAN |
| Accession Number | NP_004569 |
| Immunogen | Human |
| Immunogen Region | 1-218aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylated by CDK1 kinase during mitosis. Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB4A is involved in protein transport. Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets. |
| Protein Name | Ras-Related Protein Rab-4a |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-1660499Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8875656 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmEarly Endosome MembraneRecycling Endosome MembraneGenerally Associated With MembranesCytoplasmic When Phosphorylated By Cdk1 |
| Alternative Protein Names | Ras-Related Protein Rab-4a proteinRAB4A proteinRAB4 protein |
Information sourced from Uniprot.org