Human RAB39B protein (Recombinant) (His-Tag) (STJP018916)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RAB39B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) , 30% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB39B |
| Gene ID | 116442 |
| Uniprot ID | RB39B_HUMAN |
| Accession Number | NP_741995.1 |
| Immunogen | Human |
| Immunogen Region | 1-213aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Highly expressed in the brain. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB39B is involved in autophagy and may function in autophagosome formation. Binds downstream effector PICK1 to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR composition at the post-synapses and thus synaptic transmission. May regulate the homeostasis of SNCA/alpha-synuclein. |
| Protein Name | Ras-Related Protein Rab-39b |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmic Vesicle MembraneGolgi ApparatusCytoplasmic VesicleAutophagosome MembraneAutolysosome MembranePartial Colocalization With Markers That Cycle From The Cell Surface To The Trans-Golgi NetworkColocalized With Stx17 In Autolysosomes In Autophagy-Induced ConditionsAlthough Less Compared With Rab39a |
| Alternative Protein Names | Ras-Related Protein Rab-39b proteinRAB39B protein |
Information sourced from Uniprot.org