Human PSME3 protein (Recombinant) (N-His) (STJP011681)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PSME3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PSME3 |
| Gene ID | 10197 |
| Uniprot ID | PSME3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser111-Tyr254 |
Additional Info
| Function | Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition. |
| Protein Name | Proteasome Activator Complex Subunit 311s Regulator Complex Subunit GammaReg-GammaActivator Of Multicatalytic Protease Subunit 3Ki Nuclear AutoantigenProteasome Activator 28 Subunit GammaPa28gPa28gamma |
| Database Links | Reactome: R-HSA-9907900 |
| Cellular Localisation | NucleusCytoplasmLocalizes To The Cytoplasm During Mitosis Following Nuclear Envelope Breakdown At This Distinct Stage Of The Cell Cycle Which Allows Its Interaction With Map3k3 Kinase |
| Alternative Protein Names | Proteasome Activator Complex Subunit 3 protein11s Regulator Complex Subunit Gamma proteinReg-Gamma proteinActivator Of Multicatalytic Protease Subunit 3 proteinKi Nuclear Autoantigen proteinProteasome Activator 28 Subunit Gamma proteinPa28g proteinPa28gamma proteinPSME3 protein |
Information sourced from Uniprot.org