Recombinant human PNPT1 protein SDS-PAGE gel 3µg reducing conditions Coomassie stain

Human PNPT1 protein (Recombinant) (His-Tag) (STJP019111)

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STJP019111
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Short Description :Recombinant-Human PNPT1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.25 mg/mL
Formulation:Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:PNPT1
Gene ID:87178
Uniprot ID:PNPT1_HUMAN
Accession Number:NP_149100.2
Immunogen:Human
Immunogen Region:46-783aa
Immunogen Sequence:AVAVDLG NRKLEISSGK LARFADGSAV VQSGDTAVMV TAVSKTKPSP SQFMPLVVDY RQKAAAAGRI PTNYLRREIG TSDKEILTSR IIDRSIRPLF PAGYFYDTQV LCNLLAVDGV NEPDVLAING ASVALSLSDI PWNGPVGAVR IGIIDGEYVV NPTRKEMSSS TLNLVVAGAP KSQIVMLEAS AENILQQDFC HAIKVG
Function RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration.regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity.degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells.specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.
Protein Name Polyribonucleotide Nucleotidyltransferase 1 - Mitochondrial
3'-5' Rna Exonuclease Old35
Pnpase Old-35
Polynucleotide Phosphorylase 1
Pnpase 1
Polynucleotide Phosphorylase-Like Protein
Database Links Reactome: R-HSA-9836573
Cellular Localisation Cytoplasm
Mitochondrion Matrix
Mitochondrion Intermembrane Space
Peripheral Membrane Protein
Alternative Protein Names Polyribonucleotide Nucleotidyltransferase 1 - Mitochondrial protein
3'-5' Rna Exonuclease Old35 protein
Pnpase Old-35 protein
Polynucleotide Phosphorylase 1 protein
Pnpase 1 protein
Polynucleotide Phosphorylase-Like Protein protein
PNPT1 protein
PNPASE protein

Information sourced from Uniprot.org

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