Human PLDN protein (Recombinant) (His-Tag) (STJP017595)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PLDN-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% Glycerol, 100mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BLOC1S6 |
| Gene ID | 26258 |
| Uniprot ID | BL1S6_HUMAN |
| Accession Number | NP_036520 |
| Immunogen | Human |
| Immunogen Region | 1-172aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylated. |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. |
| Protein Name | Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 6Bloc-1 Subunit 6Pallid Protein HomologPallidinSyntaxin 13-Interacting Protein |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinIt Can Exist As A Soluble Protein As Well As A Peripheral Membrane Protein |
| Alternative Protein Names | Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 6 proteinBloc-1 Subunit 6 proteinPallid Protein Homolog proteinPallidin proteinSyntaxin 13-Interacting Protein proteinBLOC1S6 proteinPA proteinPLDN protein |
Information sourced from Uniprot.org