SDS-PAGE gel of recombinant human PIP4K2B protein under reducing conditions Coomassie blue stain

Human PIP4K2B protein (Recombinant) (His-Tag) (STJP018049)

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STJP018049
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Short Description :Recombinant-Human PIP4K2B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:PIP4K2B
Gene ID:8396
Uniprot ID:PI42B_HUMAN
Accession Number:NP_003550
Immunogen:Human
Immunogen Region:1-416aa
Immunogen Sequence:MSSNCTS TTAVAVAPLS ASKTKTKKKH FVCQKVKLFR ASEPILSVLM WGVNHTINEL SNVPVPVMLM PDDFKAYSKI KVDNHLFNKE NLPSRFKFKE YCPMVFRNLR ERFGIDDQDY QNSVTRSAPI NSDSQGRCGT RFLTTYDRRF VIKTVSSEDV AEMHNILKKY HQFIVECHGN TLLPQFLGMY RLTVDGVETY MVVTRN
Tissue Specificity Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.
Post Translational Modifications Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. Phosphorylated on serine residues.
Function Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.
Protein Name Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta
1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta
Diphosphoinositide Kinase 2-Beta
Phosphatidylinositol 5-Phosphate 4-Kinase Type Ii Beta
Pi(5p 4-Kinase Type Ii Beta
Pip4kii-Beta
Ptdins(5p-4-Kinase Isoform 2-Beta
Database Links Reactome: R-HSA-1660499
Reactome: R-HSA-6811555
Reactome: R-HSA-6811558
Reactome: R-HSA-8847453
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cell Membrane
Nucleus
Cytoplasm
Associated With The Plasma Membrane And The Endoplasmic Reticulum
Alternative Protein Names Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta protein
1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta protein
Diphosphoinositide Kinase 2-Beta protein
Phosphatidylinositol 5-Phosphate 4-Kinase Type Ii Beta protein
Pi(5p 4-Kinase Type Ii Beta protein
Pip4kii-Beta protein
Ptdins(5p-4-Kinase Isoform 2-Beta protein
PIP4K2B protein
PIP5K2B protein

Information sourced from Uniprot.org

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