Human PIP4K2B protein (Recombinant) (His-Tag) (STJP018049)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PIP4K2B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PIP4K2B |
| Gene ID | 8396 |
| Uniprot ID | PI42B_HUMAN |
| Accession Number | NP_003550 |
| Immunogen | Human |
| Immunogen Region | 1-416aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. |
| Post Translational Modifications | Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. Phosphorylated on serine residues. |
| Function | Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3. |
| Protein Name | Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-BetaDiphosphoinositide Kinase 2-BetaPhosphatidylinositol 5-Phosphate 4-Kinase Type Ii BetaPi(5p 4-Kinase Type Ii BetaPip4kii-BetaPtdins(5p-4-Kinase Isoform 2-Beta |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-6811555Reactome: R-HSA-6811558Reactome: R-HSA-8847453 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinCell MembraneNucleusCytoplasmAssociated With The Plasma Membrane And The Endoplasmic Reticulum |
| Alternative Protein Names | Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta protein1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta proteinDiphosphoinositide Kinase 2-Beta proteinPhosphatidylinositol 5-Phosphate 4-Kinase Type Ii Beta proteinPi(5p 4-Kinase Type Ii Beta proteinPip4kii-Beta proteinPtdins(5p-4-Kinase Isoform 2-Beta proteinPIP4K2B proteinPIP5K2B protein |
Information sourced from Uniprot.org