| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human PIK3R4-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | PIK3R4 |
| Gene ID: | 30849 |
| Uniprot ID: | PI3R4_HUMAN |
| Immunogen Region: | His746-Asp812 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Myristoylated. Probably autophosphorylated. |
| Function | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate.different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2. |
| Protein Name | Phosphoinositide 3-Kinase Regulatory Subunit 4Pi3-Kinase Regulatory Subunit 4Pi3-Kinase P150 SubunitPhosphoinositide 3-Kinase Adaptor Protein |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1632852Reactome: R-HSA-1660514Reactome: R-HSA-1660516Reactome: R-HSA-1660517Reactome: R-HSA-168138Reactome: R-HSA-5668599Reactome: R-HSA-9679504Reactome: R-HSA-9694676Reactome: R-HSA-9705671Reactome: R-HSA-983170 |
| Cellular Localisation | Late EndosomeCytoplasmic VesicleAutophagosomeMembraneLipid-AnchorAs Component Of The Pi3k Complex I Localized To Pre-Autophagosome StructuresAs Component Of The Pi3k Complex Ii Localized Predominantly To EndosomesLocalizes Also To Discrete Punctae Along The Ciliary Axoneme |
| Alternative Protein Names | Phosphoinositide 3-Kinase Regulatory Subunit 4 proteinPi3-Kinase Regulatory Subunit 4 proteinPi3-Kinase P150 Subunit proteinPhosphoinositide 3-Kinase Adaptor Protein proteinPIK3R4 proteinVPS15 protein |
Information sourced from Uniprot.org