Human PAPSS1 protein (Recombinant) (His-Tag) (STJP017513)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PAPSS1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PAPSS1 |
| Gene ID | 9061 |
| Uniprot ID | PAPS1_HUMAN |
| Accession Number | NP_005434 |
| Immunogen | Human |
| Immunogen Region | 24-624aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage. |
| Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate.APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells. |
| Protein Name | Bifunctional 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1Paps Synthase 1Papss 1Sulfurylase Kinase 1Sk 1Sk1 Includes - Sulfate AdenylyltransferaseAtp-SulfurylaseSulfate Adenylate TransferaseSat - Adenylyl-Sulfate Kinase3'-Phosphoadenosine-5'-Phosphosulfate SynthaseAps KinaseAdenosine-5'-Phosphosulfate 3'-PhosphotransferaseAdenylylsulfate 3'-Phosphotransferase |
| Database Links | Reactome: R-HSA-174362Reactome: R-HSA-2408550Reactome: R-HSA-6802952 |
| Cellular Localisation | |
| Alternative Protein Names | Bifunctional 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 proteinPaps Synthase 1 proteinPapss 1 proteinSulfurylase Kinase 1 proteinSk 1 proteinSk1 Includes - Sulfate Adenylyltransferase proteinAtp-Sulfurylase proteinSulfate Adenylate Transferase proteinSat - Adenylyl-Sulfate Kinase protein3'-Phosphoadenosine-5'-Phosphosulfate Synthase proteinAps Kinase proteinAdenosine-5'-Phosphosulfate 3'-Phosphotransferase proteinAdenylylsulfate 3'-Phosphotransferase proteinPAPSS1 proteinATPSK1 proteinPAPSS protein |
Information sourced from Uniprot.org