| Tissue Specificity | Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage. |
| Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate.APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells. |
| Protein Name | Bifunctional 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1Paps Synthase 1Papss 1Sulfurylase Kinase 1Sk 1Sk1 Includes - Sulfate AdenylyltransferaseAtp-SulfurylaseSulfate Adenylate TransferaseSat - Adenylyl-Sulfate Kinase3'-Phosphoadenosine-5'-Phosphosulfate SynthaseAps KinaseAdenosine-5'-Phosphosulfate 3'-PhosphotransferaseAdenylylsulfate 3'-Phosphotransferase |
| Database Links | Reactome: R-HSA-174362Reactome: R-HSA-2408550Reactome: R-HSA-6802952 |
| Cellular Localisation | |
| Alternative Protein Names | Bifunctional 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 proteinPaps Synthase 1 proteinPapss 1 proteinSulfurylase Kinase 1 proteinSk 1 proteinSk1 Includes - Sulfate Adenylyltransferase proteinAtp-Sulfurylase proteinSulfate Adenylate Transferase proteinSat - Adenylyl-Sulfate Kinase protein3'-Phosphoadenosine-5'-Phosphosulfate Synthase proteinAps Kinase proteinAdenosine-5'-Phosphosulfate 3'-Phosphotransferase proteinAdenylylsulfate 3'-Phosphotransferase proteinPAPSS1 proteinATPSK1 proteinPAPSS protein |
Information sourced from Uniprot.org
