Human PAFAH2 protein (Recombinant) (His-Tag) (STJP019128)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PAFAH2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PAFAH2 |
| Gene ID | 5051 |
| Uniprot ID | PAFA2_HUMAN |
| Accession Number | NP_000428 |
| Immunogen | Human |
| Immunogen Region | 1-392aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMGVNQSV GFPPVTGPHL VGCGDVMEGQ NLQGSFFRLF YPCQKAEETM EQPLWIPRYE YCTGLAEYLQ FNKRCGGLLF NLAVGSCRLP VSWNGPFKTK DSGYPLIIFS HGLGAFRTLY SAFCMELASR GFVVAVPEHR DRSAATTYFC KQAPEENQPT NESLQEEWIP FRRVEEGEKE FHVRNPQVHQ RVSECLRVLK ILQEVTAG |
Additional Info
| Tissue Specificity | Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex. |
| Function | Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation. Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF. Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. |
| Protein Name | Platelet-Activating Factor Acetylhydrolase 2 - CytoplasmicPaf -Lysophospholipid TransacetylasePaf -Sphingosine TransacetylasePlatelet-Activating Factor Acetyltransferase Pafah2Serine-Dependent Phospholipase A2Sd-Pla2Hsd-Pla2 |
| Database Links | Reactome: R-HSA-418346 |
| Cellular Localisation | CytoplasmMembraneLipid-AnchorEndoplasmic Reticulum MembraneIn Resting CellsLocalizes To Intracellular Membranes And CytoplasmTranslocates From The Cytoplasm To Intracellular Membranes Upon Oxidative Stress |
| Alternative Protein Names | Platelet-Activating Factor Acetylhydrolase 2 - Cytoplasmic proteinPaf -Lysophospholipid Transacetylase proteinPaf -Sphingosine Transacetylase proteinPlatelet-Activating Factor Acetyltransferase Pafah2 proteinSerine-Dependent Phospholipase A2 proteinSd-Pla2 proteinHsd-Pla2 proteinPAFAH2 protein |
Information sourced from Uniprot.org