Human OGG1 protein (Recombinant) (His-Tag) (STJP016808)

SKU:
STJP016808
£134.50 - £738.50
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Short Description :Recombinant-Human OGG1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in phosphate-Buffered Saline (pH 7.4) containing 40% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:OGG1
Gene ID:4968
Uniprot ID:OGG1_HUMAN
Accession Number:AAH00657.1
Immunogen:Human
Immunogen Region:1-345aa
Immunogen Sequence:MPARALL PRRMGHRTLA STPALWASIP CPRSELRLDL VLPSGQSFRW REQSPAHWSG VLADQVWTLT QTEEQLHCTV YRGDKSQASR PTPDELEAVR KYFQLDVTLA QLYHHWGSVD SHFQEVAQKF QGVRLLRQDP IECLFSFICS SNNNIARITG MVERLCQAFG PRLIQLDDVT YHGFPSLQAL AGPEVEAHLR KLGLGY
Tissue Specificity Ubiquitous.
Function DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Protein Name N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site Lyase
Ap Lyase
Database Links Reactome: R-HSA-110328
Reactome: R-HSA-110329
Reactome: R-HSA-110330
Reactome: R-HSA-110331
Reactome: R-HSA-110357
Reactome: R-HSA-5649702
Reactome: R-HSA-9656255
Reactome: R-HSA-9656256
Reactome: R-HSA-9657050 O15527-4
Cellular Localisation Nucleus
Nucleoplasm
Nucleus Speckle
Nucleus Matrix
Together With Apex1 Is Recruited To Nuclear Speckles In Uva-Irradiated Cells
Isoform 1a: Nucleus
Isoform 2a: Mitochondrion
Alternative Protein Names N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site Lyase protein
Ap Lyase protein
OGG1 protein
MMH protein
MUTM protein
OGH1 protein

Information sourced from Uniprot.org