| Short Description : | Recombinant-Human NRGN/Neurogranin-C-hFC protein was developed in hek293 cells using the region Asp2-Asp78. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of 20mM Tris 150mM Nacl, pH 7.5. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g |
| Gene Symbol: | NRGN |
| Gene ID: | 4900 |
| Uniprot ID: | NEUG_HUMAN |
| Immunogen: | Recombinant Human NRGN/Neurogranin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp2-Asp78) of human NRGN/Neurogranin (Accession #) fused with hFc tag at the C-terminus. |
| Immunogen Region: | Asp2-Asp78 |
| Immunogen Sequence: | DCCTENACSKPDDDILDIPL DDPGANAAAAKIQASFRGHM ARKKIKSGERGRKGPGPGGP GGAGVARGGAGGGPSGD |
| Post Translational Modifications | Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions. |
| Function | Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. |
| Protein Name | NeurograninNgRc3 Cleaved Into - Neug(55-78 |
| Database Links | Reactome: R-HSA-9620244 |
| Cellular Localisation | |
| Alternative Protein Names | Neurogranin proteinNg proteinRc3 Cleaved Into - Neug(55-78 proteinNRGN protein |
Information sourced from Uniprot.org
