Human NRGN/Neurogranin protein (Recombinant) (C-hFC) (STJP001978)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human NRGN/Neurogranin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp2-Asp78) of human NRGN/Neurogranin (Accession #) fused with hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human NRGN/Neurogranin-C-hFC protein was developed in hek293 cells using the region Asp2-Asp78. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of 20mM Tris 150mM Nacl, pH 7.5. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.01 EU/Mu g |
Target Information
| Gene Symbol | NRGN |
| Gene ID | 4900 |
| Uniprot ID | NEUG_HUMAN |
| Immunogen | Recombinant Human NRGN/Neurogranin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp2-Asp78) of human NRGN/Neurogranin (Accession #) fused with hFc tag at the C-terminus. |
| Immunogen Region | Asp2-Asp78 |
| Immunogen Sequence | DCCTENACSKPDDDILDIPL DDPGANAAAAKIQASFRGHM ARKKIKSGERGRKGPGPGGP GGAGVARGGAGGGPSGD |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions. |
| Function | Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. |
| Protein Name | NeurograninNgRc3 Cleaved Into - Neug(55-78 |
| Database Links | Reactome: R-HSA-9620244 |
| Cellular Localisation | |
| Alternative Protein Names | Neurogranin proteinNg proteinRc3 Cleaved Into - Neug(55-78 proteinNRGN protein |
Information sourced from Uniprot.org